Steric effects at acyclic and bridgehead carbons attached to carbonyls

Authors

David S. Kristol, New Jersey Institute of Technology
Mark A. Fisher, New Jersey Institute of Technology
Janardan Yadav, Rutgers Biomedical and Health Sciences
Swamy Laxminarayan, Rutgers Biomedical and Health Sciences
Howard Perlmutter, New Jersey Institute of Technology

Document Type

Conference Proceeding

Publication Date

1-1-1992

Abstract

The rates of alkaline hydrolysis of seven acyclic and bridgehead esters of p-nitrophenyl carboxylic acids have been kinetically found to vary inversely with the size of the substituent R group. Computer assisted molecular modeling techniques were used to suggest a steric and electrostatic rationale for the effect of R group size upon the rate of hydrolysis.

Identifier

85067001084 (Scopus)

ISBN

[0780307852]

Publication Title

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

External Full Text Location

https://doi.org/10.1109/IEMBS.1992.5760930

ISSN

1557170X

First Page

211

Last Page

212

Volume

1

Recommended Citation

Kristol, David S.; Fisher, Mark A.; Yadav, Janardan; Laxminarayan, Swamy; and Perlmutter, Howard, "Steric effects at acyclic and bridgehead carbons attached to carbonyls" (1992). Faculty Publications. 17397.
https://digitalcommons.njit.edu/fac_pubs/17397