Adiabatic Kinetic Studies of the Cytidine/Acetic Anhydride Reaction by Utilizing Temperature versus Time Data

Document Type

Article

Publication Date

1-1-1993

Abstract

It is possible to predict the kinetics of a reaction by using temperature versus time data under adiabatic conditions. This method was used for the cytidine/acetic anhydride batch reaction using a Mettler RC1 reaction calorimeter. The authenticity of the experimental adiabatic system was verified by determining the kinetic parameters of a known reaction (hydrolysis of acetic anhydride) and comparing them to literature values. The cytidine/acetic anhydride reaction (unknown system) was subjected to the same adiabatic analysis, and the average experimental activation energy, heat of reaction, and In k0 values were 13.3 ± 0.2 kcal/g-mol, −10.5 ± 0.1 kcal/g-mol, and 15.68 ± 0.34 L/(g-mol·s), respectively. To further verify the results for the unknown system, three isothermal runs were executed and samples were analyzed for concentration by high-pressure liquid chromatography (HPLC). The concentration-time data were analyzed, and an Arrhenius plot was constructed yielding an activation energy of 13.2 kcal/g-mol and a In k0 value of 15.14 L/(g-mol·s). These isothermal runs agreed very well with the data obtained from the adiabatic runs. The reaction was second order. © 1993, American Chemical Society. All rights reserved.

Identifier

0027578901 (Scopus)

Publication Title

Industrial and Engineering Chemistry Research

External Full Text Location

https://doi.org/10.1021/ie00016a004

e-ISSN

15205045

ISSN

08885885

First Page

594

Last Page

599

Issue

4

Volume

32

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