Three-dimensional bioprinting vascularized bone tissue

Document Type

Article

Publication Date

6-1-2023

Abstract

Currently available bone grafts are insufficient to address the demand and lack tissue complexity to mimic the native bone tissue microenvironment. Bone tissue is highly vascular, and vasculature is crucial for bone tissue development and functional integration of the graft to the native defect site. Three-dimensional (3D) bioprinting has emerged as an advanced biomanufacturing technology to develop vascularized bone tissue with architectural, structural, biochemical, and cellular complexity. This article includes currently available 3D bioprinting technologies and corresponding bioinks followed by a detailed review on 3D bioprinting strategies for vasculature. Finally, the current state of the art in 3D bioprinting of vascularized bone tissue is presented. Graphical abstract: [Figure not available: see fulltext.].

Identifier

85161416881 (Scopus)

Publication Title

MRS Bulletin

External Full Text Location

https://doi.org/10.1557/s43577-023-00547-y

ISSN

08837694

First Page

668

Last Page

675

Issue

6

Volume

48

Grant

2044479

Fund Ref

National Science Foundation

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