Protein concentration effect on protein-lipopolysaccharide (LPS) binding and endotoxin removal

Document Type

Article

Publication Date

4-5-1997

Abstract

It is known some proteins can disaggregate endotoxins and form complexes with lipopolysaccharide (LPS). Nevertheless, how protein concentration affects protein-LPS binding and endotoxin removal is unknown. In this study, protein samples at various concentrations were incubated with endotoxin samples at a fixed concentration. The mixtures were filtered by ultrafiltration membranes. As protein concentration increased, the amount of endotoxin detected in the filtrates increased too. This result indicates protein concentration has significant effect on protein-LPS binding and the amount of endotoxin disaggregated.

Identifier

0030937589 (Scopus)

Publication Title

Biotechnology Letters

External Full Text Location

https://doi.org/10.1023/A:1018304128932

ISSN

01415492

First Page

135

Last Page

138

Issue

2

Volume

19

Fund Ref

Colgate-Palmolive Company

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