A reservoir-type controlled release device using aqueous-organic partitioning and a porous membrane

Document Type

Article

Publication Date

7-23-1997

Abstract

A reservoir-type controlled release device based on aqueous-organic partitioning is described. The reservoir is bounded by a microporous or porous membrane, either a hollow fiber or a flat film. The agent partitions between phases at the aqueous-organic interface of the reservoir and the pore mouth, and then diffuses through the membrane pore into a surrounding aqueous solution. The partition coefficient significantly influences the rate of release of the agent. The performance of the system is evaluated using model agents. Controlled release from a reservoir containing a pure organic liquid agent is demonstrated using toluene. Zero-order release is achieved for benzoic acid partitioning from an organic reservoir into water-filled pores, and for nicotine partitioning from an aqueous reservoir into organic-filled pores. Studies using benzoic acid demonstrate the effectiveness of a thin, nonporous coating on slowing the rate of release. A fast-dissolving suspension of benzoic acid in decanol extends the duration of zero-order release. Two agents, nicotine and caffeine, are released simultaneously and independently from a divided reservoir. A simplified mathematical model is presented, and experimental results compared well with those predicted by the model.

Identifier

0343329865 (Scopus)

Publication Title

Journal of Membrane Science

External Full Text Location

https://doi.org/10.1016/S0376-7388(96)00343-2

ISSN

03767388

First Page

265

Last Page

274

Issue

1-2

Volume

130

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