Anti-inflammatory properties of triblock siloxane copolymer-blended materials

Document Type

Article

Publication Date

8-1-1999

Abstract

Implantable biomaterials often trigger a variety of adverse responses. Because polydimethyl siloxane surfaces have good hemo- and bio-compatibility, it is generally believed that surface biocompatibility may be improved by modifying biomaterial surfaces with silicone-like properties. For this, we developed a series of polycaprolactone-polydimethylsiloxane-polycaprolactone (PDMS-PCL) copolymers. By mixing the substrate material - polyvinyl chloride - with low concentrations (1.2 and 2.4%) of the PDMS-PCL copolymer, we generated materials with silicone-like surface properties as reflected by increased surface silicon content and surface contact angles. We assessed the biocompatibility of these surfaces in vitro and found that the addition of PDMS-PCL significantly reduced the percentages of surface-'denatured' fibrinogen, a critical element of genesis of many adverse responses to implanted biomaterials. Indeed, using an animal implantation model, we find that PDMS-PCL-blended materials triggered significantly weaker inflammatory responses than did polyvinyl chloride, the substrate control. The results from these experiments suggest that the use of PDMS-PCL additives (2.4%) in polymer blends is a useful means of camouflaging the substrate surface properties and improving the biocompatibility of biomaterials.

Identifier

0033179458 (Scopus)

Publication Title

Biomaterials

External Full Text Location

https://doi.org/10.1016/S0142-9612(99)00034-4

ISSN

01429612

PubMed ID

10454007

First Page

1365

Last Page

1370

Issue

15

Volume

20

Grant

004949-010

Fund Ref

National Institutes of Health

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