Neural mechanisms for generating rate and temporal codes in model CA3 pyramidal cells

Document Type

Article

Publication Date

1-1-2001

Abstract

The effect of synaptic inhibition on burst firing of a two-compartment model of a CA3 pyramidal cell is considered. We show that, depending on its timing, a short dose of fast decaying synaptic inhibition can either delay or advance the timing of firing of subsequent bursts. Moreover, increasing the strength of the inhibitory input is shown to modulate the burst profile from a full complex burst, to a burst with multiple spikes, to single spikes. We additionally show how slowly decaying inhibitory input can be used to synchronize a network of pyramidal cells. Implications for the phase precession phenomenon of hippocampal place cells and for the generation of temporal and rate codes are discussed.

Identifier

0035005641 (Scopus)

Publication Title

Journal of Neurophysiology

External Full Text Location

https://doi.org/10.1152/jn.2001.85.6.2432

ISSN

00223077

PubMed ID

11387389

First Page

2432

Last Page

2445

Issue

6

Volume

85

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