Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

Authors

Guosheng Wu, ChemPacific Corporation
Hua Zhao, Newark College of Engineering
Robert G. Luo, Newark College of Engineering
Dean Wei, ChemPacific Corporation
Sanjay V. Malhotra, Newark College of Engineering

Document Type

Article

Publication Date

12-1-2001

Abstract

Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.

Identifier

0035754295 (Scopus)

Publication Title

Enantiomer

ISSN

10242430

PubMed ID

11958341

First Page

343

Last Page

345

Issue

6

Volume

6

Recommended Citation

Wu, Guosheng; Zhao, Hua; Luo, Robert G.; Wei, Dean; and Malhotra, Sanjay V., "Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase" (2001). Faculty Publications. 15064.
https://digitalcommons.njit.edu/fac_pubs/15064