In Vitro Models for Peripheral Nerve Regeneration

Document Type

Article

Publication Date

12-4-2024

Abstract

Peripheral nerve injury (PNI) resulting in lesions is highly prevalent clinically, but current therapeutic approaches fail to provide satisfactory outcomes in many patients. While peripheral nerves have intrinsic regenerative capacity, the regenerative capabilities of peripheral nerves are often insufficient to restore full functionality. This highlights an unmet need for developing more effective strategies to repair damaged peripheral nerves and improve regenerative success. Consequently, researchers are actively exploring a variety of therapeutic strategies, encompassing the local delivery of trophic factors or bioactive molecules, the design of advanced biomaterials that interact with regenerating axons, and augmentation with nerve guidance conduits or complex prostheses. However, clinical translation of these technologies remains limited, emphasizing the need for continued research on peripheral nerve regeneration modalities that can enhance functional restoration. Experimental models that accurately recapitulate key aspects of peripheral nerve injury and repair biology can accelerate therapeutic development by enabling systematic testing of new techniques. Advancing regenerative therapies for PNI requires bridging the gap between basic science discoveries and clinical application. This review discusses different in vitro models of peripheral nerve injury and repair, including their advantages, limitations, and potential applications.

Identifier

85204762261 (Scopus)

Publication Title

Advanced Healthcare Materials

External Full Text Location

https://doi.org/10.1002/adhm.202401605

e-ISSN

21922659

ISSN

21922640

PubMed ID

39324286

Issue

30

Volume

13

Grant

KL2‐TR003018 & R21‐AR079708

Fund Ref

New Jersey Institute of Technology

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