1H and 13C NMR structural studies of amiloride in cryosolvents

Authors

William J. Skawinski, New Jersey Institute of Technology
Ana Ofsievich, New Jersey Institute of Technology
Carol A. Venanzi, New Jersey Institute of Technology

Document Type

Article

Publication Date

2-1-2002

Abstract

Amiloride hydrochloride is a potent inhibitor of several cellular ion transport systems and has been used as a diuretic drug and a probe of ion transport processes. ¹H and ¹³C NMR studies have been carried out at a proton field strength of 400 MHz in DMSO/CH2Cl 2 and DMF cryosolvents over a temperature range from 20 to -55°C in order to investigate the conformations of the hydrochloride and its free-base form in solution. Resonances for all protons have been assigned. The results of double resonance and NOE experiments suggest that the structures in solution are most likely planar and consistent with previously reported computational results.

Identifier

1842578438 (Scopus)

Publication Title

Structural Chemistry

External Full Text Location

https://doi.org/10.1023/A:1013425431416

ISSN

10400400

First Page

73

Last Page

80

Issue

1

Volume

13

Fund Ref

American Chemical Society

Recommended Citation

Skawinski, William J.; Ofsievich, Ana; and Venanzi, Carol A., "1H and 13C NMR structural studies of amiloride in cryosolvents" (2002). Faculty Publications. 14737.
https://digitalcommons.njit.edu/fac_pubs/14737