Modeling the effect of biophysical parameters on mass transport in capillary networks

Document Type

Conference Proceeding

Publication Date

12-1-2002

Abstract

This paper describes a generalization to other chemical species of a previously developed computational model of oxygen transport in capillary networks. In particular, the transport of larger molecules is considered. A steady-state transport model is described for the case where the species of interest is carried mainly in dissolved form in the blood and the systemic concentration is fixed. A simplified one-dimensional version of this model is solved analytically to show how transport might be affected by biophysical parameters such as the diffusion constant and rate of degradation in the tissue. A three-dimensional, striated muscle capillary network is being used in numerical simulations to determine the effects of these parameters in the full model. Results of sample calculations are presented.

Identifier

0036916044 (Scopus)

Publication Title

Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings

ISSN

05891019

First Page

1515

Last Page

1516

Volume

2

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