Combined effect of mercuric ion and silver ion on the clotting time of blood

Authors

Uma R. Phatak, New Jersey Institute of Technology
David Kristol, New Jersey Institute of Technology
Rohit R. Arora, Rutgers New Jersey Medical School
Charles R. Spillert, Rutgers New Jersey Medical School

Document Type

Conference Proceeding

Publication Date

1-1-2003

Abstract

Mercuric ion (Hg²⁺) has been shown to have a procoagulant effect on citrated whole blood through its excitation of the extrinsic pathway. Silver ion (Ag⁺) affects the intrinsic pathway of blood coagulation also producing a shortened clotting time. This in vitro study involved mixing citrated whole blood (CWB) with mercuric nitrate Hg(NO3)2, silver nitrate AgNO3, and the combination of the two. The eight samples were incubated for ten minutes at 37°C and were analyzed by an Amelung KC 4A clot detector. The results show that the combination of Ag ⁺ and Hg²⁺ significantly reduces the clotting time (p < .002).

Identifier

84943404883 (Scopus)

Publication Title

Proceedings of the IEEE Annual Northeast Bioengineering Conference Nebec

e-ISSN

21607001

ISSN

1071121X

First Page

255

Recommended Citation

Phatak, Uma R.; Kristol, David; Arora, Rohit R.; and Spillert, Charles R., "Combined effect of mercuric ion and silver ion on the clotting time of blood" (2003). Faculty Publications. 14380.
https://digitalcommons.njit.edu/fac_pubs/14380