Lithium diisopinocampheylamide: A new and highly effective chiral catalyst in the enantioselective deprotonation of meso-epoxides

Document Type

Article

Publication Date

3-21-2003

Abstract

α-Pinene based novel chiral lithium amides have been used for the catalytic enantioselective deprotonation of cyclohexene oxide. An enantiomeric excess of up to 95% for (R)-2-scyclohexen-1-ol was achieved with lithium (-)-N,N-diisopinocampheylamide. A systematic study shows that the isopinocampheyl moiety plays an important role in achieving high enantioselectivity. © 2003 Elsevier Science Ltd. All rights reserved.

Identifier

0037459228 (Scopus)

Publication Title

Tetrahedron Asymmetry

External Full Text Location

https://doi.org/10.1016/S0957-4166(03)00080-6

ISSN

09574166

First Page

645

Last Page

647

Issue

6

Volume

14

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