Neural engineering to produce in vitro nerve constructs and neurointerface

Document Type

Article

Publication Date

1-1-2007

Abstract

OBJECTIVE: Recently, our laboratory recapitulated a natural form of axon growth that occurs between late embryogenesis and early adulthood. In this article, we describe how this novel neural engineering approach may be used to produce a nervous tissue interface to integrate disconnected motor and sensory functions for external control. METHODS: For nervous system repair, we recently developed a unique method to engineer nervous tissue constructs in vitro consisting of bundles of axons spanning two populations of neuronal somata. To integrate electronics and nervous tissue to transform electrophysiological signals into electronic signals, we have designed a nervous tissue interface. RESULTS: Our nervous tissue interface consists of stretch-grown nervous tissue with one end interfaced with a multiple electrode array, enabling us to detect and record real-time efferent signals conducted down the nerve and stimulate afferent sensory signaling. CONCLUSION: Our ultimate goal is to develop a neurally controlled prosthesis and a nervous system interface that could be linked to the patient's thoughts, providing two-way signaling for motor control and feedback from multiple external stimuli. Copyright © by the Congress of Neurological Surgeons.

Identifier

33846262011 (Scopus)

Publication Title

Neurosurgery

External Full Text Location

https://doi.org/10.1227/01.NEU.0000249197.61280.1D

ISSN

0148396X

PubMed ID

17228262

First Page

137

Last Page

142

Issue

1

Volume

60

Grant

F32NS046170

Fund Ref

National Institute of Neurological Disorders and Stroke

This document is currently not available here.

Share

COinS