Daily oscillations of neuronal membrane capacitance

Document Type

Article

Publication Date

10-22-2024

Abstract

Capacitance of biological membranes is determined by the properties of the lipid portion of the membrane as well as the morphological features of a cell. In neurons, membrane capacitance is a determining factor of synaptic integration, action potential propagation speed, and firing frequency due to its direct effect on the membrane time constant. Besides slow changes associated with increased morphological complexity during postnatal maturation, neuronal membrane capacitance is considered a stable, non-regulated, and constant magnitude. Here we report that, in two excitatory neuronal cell types, pyramidal cells of the mouse primary visual cortex and granule cells of the hippocampus, the membrane capacitance significantly changes between the start and the end of a daily light-dark cycle. The changes are large, nearly 2-fold in magnitude in pyramidal cells, but are not observed in cortical parvalbumin-expressing inhibitory interneurons. Consistent with daily capacitance fluctuations, the time window for synaptic integration also changes in pyramidal cells.

Identifier

85207664370 (Scopus)

Publication Title

Cell Reports

External Full Text Location

https://doi.org/10.1016/j.celrep.2024.114744

e-ISSN

22111247

ISSN

26391856

PubMed ID

39298314

Issue

10

Volume

43

Grant

5R01-EY12124

Fund Ref

National Institutes of Health

This document is currently not available here.

Share

COinS