A novel neuroprosthetic interface with the peripheral nervous system using artificially engineered axonal tracts

Document Type

Article

Publication Date

12-1-2008

Abstract

Objective: We have previously described a technique developed in our laboratory to create transplantable living axon tracts of several centimeters in length. In this paper, we describe how these engineered neural tissue constructs can be used to create a novel neuroelectrical interface with the regenerating peripheral nervous system, to potentially enable afferent and efferent communications with prosthetic devices. Methods: Using continuous mechanical tension, we have generated axon tracts of up to 10 cm in length, spanning two populations of neurons in vitro. We have now adapted this stretch-growth paradigm to include a mechanically compliant multi-electrode array that is attached to one of the neuron populations. Once the desired axon length has been reached, the neuroelectrode construct is completely embedded in a supportive hydrogel matrix and affixed to the transected sciatic nerve. Results: Building upon our previous work with peripheral nerve repair, we have designed our neural interface to ensure transplant stability and firm attachment to the electrode array substrate. Discussion: Our preliminary findings indicate that the interface not only maintains its orientation, but also is conducive to host nerve ingrowth. Our ongoing analysis seeks to characterize transplanted neuronal survival, synaptic integration, and functional connectivity. This research provides an opportunity to evaluate an entirely new approach in restoring motor and sensory functions of patients with peripheral nerve damage. © 2008 W. S. Maney & Son Ltd.

Identifier

57449104193 (Scopus)

Publication Title

Neurological Research

External Full Text Location

https://doi.org/10.1179/174313208X362541

ISSN

01616412

PubMed ID

19079981

First Page

1063

Last Page

1067

Issue

10

Volume

30

Grant

R01NS048949

Fund Ref

National Institute of Neurological Disorders and Stroke

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