Nano-scale debye capacitive sensors for highly sensitive, and label-free, nucleic acid analysis

Document Type

Conference Proceeding

Publication Date

12-1-2009

Abstract

An electrochemical capacitive sensor with electrode separation in the order of the Electrical Double Layer width (Debye length) of the analyte solution is presented for extremely sensitive and label-free analysis of Nucleic Acids. As the Electrical Double Layers (EDL) from both the capacitive electrodes interact and overlap each other in the reduced space confinement, the contribution from the electrode polarization effects and noises due to bulk sample resistance are found to be minimized. The dielectric property changes during hybridization reaction were measured using 10-mer nucleotide sequences. A 30-45% change in relative permittivity (capacitance) was observed due to DNA hybridization at 10Hz. © 2009 Materials Research Society.

Identifier

77954265346 (Scopus)

ISBN

[9781617383946]

Publication Title

Materials Research Society Symposium Proceedings

ISSN

02729172

First Page

54

Last Page

59

Volume

1138

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