Design and implementation of a novel superfusion system for ex vivo characterization of neural tissue by dielectric spectroscopy (DS)

Document Type

Article

Publication Date

1-1-2011

Abstract

Dielectric spectroscopy is a widely utilized electrophysiological characterization method. The obtained dielectric spectra and derived properties have the potential of providing significant information regarding changes in the physiological state of a biological system. However, since many of the dielectric properties are obtained in vitro from excised tissue far removed from physiological conditions, the value of the information obtained may be diminished. In this paper, we introduce a superfusion system that is designed to produce ex vivo dielectric spectroscopy measurements by providing the living tissue with a continuous and ample supply of nutrients and oxygen while removing metabolites and other waste. This superfusion system provides the convenience of in vitro measurement while concurrently producing results that can be more closely correlated with actual physiological changes in the biological system. © 2011 Institute of Physics and Engineering in Medicine.

Identifier

79551477150 (Scopus)

Publication Title

Physiological Measurement

External Full Text Location

https://doi.org/10.1088/0967-3334/32/2/004

e-ISSN

13616579

ISSN

09673334

First Page

195

Last Page

205

Issue

2

Volume

32

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