Collagen-based fiber-gel constructs engineered for Schwann cell guidance and adult axon growth
Document Type
Conference Proceeding
Publication Date
6-16-2011
Abstract
Adult Schwann cells cultured within three-dimensional (3D) collagen-based nervous tissue constructs demonstrated downstream migration and potential use in the contact-guidance of regenerating adult dorsal root ganglia (DRG) axons. Type I collagen extracted from rat tail tendons was used to prepare collagen dispersions for wet spinning micron-size collagen fibers. Biodegradable poly-L-lactic acid (PLLA) and wet-spun collagen fibers containing various extracellular matrix (ECM) proteins were used to evaluate Schwann cell guidance and survival of primary adult rat DRGs, which presents a more realistic model for studying regenerative processes. © 2011 IEEE.
Identifier
79958736774 (Scopus)
ISBN
[9781612848273]
Publication Title
2011 IEEE 37th Annual Northeast Bioengineering Conference Nebec 2011
External Full Text Location
https://doi.org/10.1109/NEBC.2011.5778694
Recommended Citation
Siriwardane, M. L.; DeRosa, K. E.; and Pfister, B. J., "Collagen-based fiber-gel constructs engineered for Schwann cell guidance and adult axon growth" (2011). Faculty Publications. 11309.
https://digitalcommons.njit.edu/fac_pubs/11309
