Synthesis and immobilization of micro-scale drug particles in cellulosic films

Document Type

Article

Publication Date

8-1-2011

Abstract

The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min. © 2011 Elsevier B.V.

Identifier

79955804709 (Scopus)

Publication Title

Colloids and Surfaces B Biointerfaces

External Full Text Location

https://doi.org/10.1016/j.colsurfb.2011.03.040

ISSN

09277765

PubMed ID

21524894

First Page

181

Last Page

188

Issue

1

Volume

86

Grant

EEC-0540855

Fund Ref

National Science Foundation

This document is currently not available here.

Share

COinS