Hot melt mixing of indomethacin and Soluplus® for oral delivery

Document Type

Conference Proceeding

Publication Date

8-23-2011

Abstract

An amorphous solid suspension for oral drug delivery was prepared via Hot Melt mixing 30wt% of Indomethacin (INM) with Soluplus® (polymeric excipient). The melt mixed sample was characterized through optical microscopy, DSC, FR-IR and XRD. Dissolution test showed that INM release was pH-dependent; in the case of the amorphous solid suspension within 1h 90% of INM was released at pH7.4, while only 0.02% at pH1.2, probably a consequence of hydrogen bonds formed between INM and the polymer. The fastest release was obtained from the foamed amorphous solid suspension, followed by un-foamed amorphous solid suspension, then pure INM and finally the physical mixture.

Identifier

80051822141 (Scopus)

ISBN

[9781617829604]

Publication Title

Annual Technical Conference ANTEC Conference Proceedings

First Page

1253

Last Page

1258

Volume

2

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