A Highly Selective Fluorescence Turn-On Sensor for Extracellular Calcium Ion Detection

Authors

Binglin Sui, New Jersey Institute of Technology
Xinglei Liu, New Jersey Institute of Technology
Mengyuan Wang, University of Central Florida
Kevin D. Belfield, New Jersey Institute of Technology

Document Type

Article

Publication Date

7-18-2016

Abstract

A highly water-soluble, fluorescence turn-on sensor for Ca²⁺is reported. The sensor affords high selectivity in sensing Ca²⁺over other biologically important metal cations. The dissociation constant of the sensor in binding Ca²⁺is 0.92 mm. Fluorescence microscopy experiments demonstrate that the sensor is cell-impermeable and capable of detecting extracellular Ca²⁺.

Identifier

84977117669 (Scopus)

Publication Title

Chemistry A European Journal

External Full Text Location

https://doi.org/10.1002/chem.201602162

e-ISSN

15213765

ISSN

09476539

First Page

10351

Last Page

10354

Issue

30

Volume

22

Grant

CBET-1517273

Fund Ref

National Science Foundation

Recommended Citation

Sui, Binglin; Liu, Xinglei; Wang, Mengyuan; and Belfield, Kevin D., "A Highly Selective Fluorescence Turn-On Sensor for Extracellular Calcium Ion Detection" (2016). Faculty Publications. 10378.
https://digitalcommons.njit.edu/fac_pubs/10378