Biomaterials in siRNA Delivery: A Comprehensive Review

Document Type

Article

Publication Date

11-9-2016

Abstract

With the dearth of effective treatment options for prominent diseases including Ebola and cancer, RNA interference (RNAi), a sequence-specific mechanism for genetic regulation that can silence nearly any gene, holds the promise of unlimited potential in treating illness ever since its discovery in 1999. Given the large size, unstable tertiary structure in physiological conditions and negative charge of small interfering RNAs (siRNAs), the development of safe and effective delivery vehicles is of critical importance in order to drive the widespread use of RNAi therapeutics into clinical settings. Immense amounts of time and billions of dollars have been devoted into the design of novel and diverse delivery strategies, and there are a handful of delivery systems that have been successfully translated into clinic. This review provides an introduction to the in vivo barriers that need to be addressed by siRNA delivery systems. We also discuss the progress up to the most effective and clinically advanced siRNA delivery systems including liposomal, polymeric and siRNA conjugate delivery systems, as well as their design to overcome the challenges.

Identifier

84990201826 (Scopus)

Publication Title

Advanced Healthcare Materials

External Full Text Location

https://doi.org/10.1002/adhm.201600418

e-ISSN

21922659

ISSN

21922640

PubMed ID

27700013

First Page

2715

Last Page

2731

Issue

21

Volume

5

This document is currently not available here.

Share

COinS