Date of Award

Fall 2017

Document Type


Degree Name

Doctor of Philosophy in Biomedical Engineering - (Ph.D.)


Biomedical Engineering

First Advisor

Bryan J. Pfister

Second Advisor

N. Chandra

Third Advisor

James Haorah

Fourth Advisor

Vijayalakshmi Santhakumar

Fifth Advisor

Kevin Pang


Repetitive mTBI and concussion are a major risk factor for developing long-term cognitive and behavioral impairments. Curiously, cumulative head injuries sustained over an individuals’ career, involving contact activities (e.g. athletes and military personnel), are beginning to be implicated in long-term consequences, such as dementia. Recently, chronic traumatic encephalopathy (CTE) has gained momentum in the science and medical community as a neurodegenerative disease of repetitive head injuries. CTE was observed at autopsy of former athletes that did not closely correlate with a clinical history of concussion. Thus, suggesting cumulative subconcussive insults may induce long-term damage.