Date of Award
Doctor of Philosophy in Biology - (Ph.D.)
Federated Department of Biological Sciences
Horacio G. Rotstein
Jorge P. Golowasch
Michael Philip Nusbaum
In response to oscillatory input, many isolated neurons exhibit a preferred frequency response in their voltage amplitude and phase shift. Membrane potential resonance (MPR), a maximum amplitude in a neuron’s input impedance at a non-zero frequency, captures the essential subthreshold properties of a neuron, which may provide a coordinating mechanism for organizing the activity of oscillatory neuronal networks around a given frequency. In the pyloric central pattern generator network of the crab Cancer borealis, for example, the pacemaker group pyloric dilator neurons show MPR at a frequency that is correlated with the network frequency. This dissertation uses the crab pyloric CPG to examine how, in one neuron type, interactions of ionic currents, even when expressed at different levels, can produce consistent MPR properties, how MPR properties are modified by neuromodulators and how such modifications may lead to distinct functional effects at different network frequencies.
Fox, David Michael, "Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks" (2017). Dissertations. 52.