Date of Award

Spring 2017

Document Type


Degree Name

Doctor of Philosophy in Computing Sciences - (Ph.D.)


Computer Science

First Advisor

Jason T. L. Wang

Second Advisor

Zhi Wei

Third Advisor

Ali Mili

Fourth Advisor

David Nassimi

Fifth Advisor

MengChu Zhou


Gene network inference and drug response prediction are two important problems in computational biomedicine. The former helps scientists better understand the functional elements and regulatory circuits of cells. The latter helps a physician gain full understanding of the effective treatment on patients. Both problems have been widely studied, though current solutions are far from perfect. More research is needed to improve the accuracy of existing approaches.