Date of Award

5-31-2020

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Biomedical Engineering - (Ph.D.)

Department

Biomedical Engineering

First Advisor

Mesut Sahin

Second Advisor

Eric J. Lang

Third Advisor

Sergei Adamovich

Fourth Advisor

Bart Krekelberg

Fifth Advisor

Gail Forrest

Abstract

Non-invasive brain stimulation (NIBS) techniques garner significant interest due to their potential to offer instantaneous and region-specific treatments to neurological disorders. The cerebellum is one of the target sites for NIBS methods due to its central role in motor and cognitive functions. Among several modulation techniques, transcranial electric stimulations (tEs), in particular, transcranial direct and alternating current stimulations (tDCs/tACs), and low intensity focused ultrasound stimulation (LIFUS) show encouraging outcomes in clinical applications. tDCs and tACs are favored due to their low cost and accessibility while LIFUS offers high spatial resolution and deeper penetration without affecting the surrounding structures. In order to better understand the underlying mechanism of these methods in the cerebellum, animal studies are needed since these experiments require invasive surgeries. The goal of this study is to investigate the response of cerebellar PCs to electric and ultrasound stimulation in an animal model.

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