Date of Award

Spring 1982

Document Type

Dissertation

Degree Name

Doctor of Engineering Science in Chemical Engineering

Department

Chemical Engineering and Chemistry

First Advisor

Ching-Rong Huang

Second Advisor

Edward Charles Roche, Jr.

Third Advisor

Mahmoud F. Abd-El-Bary

Fourth Advisor

Jay Kappraff

Fifth Advisor

Dimitrios P. Tassios

Abstract

The separation of protein mixtures via pH-parametric pumping was investigated both theoretically and experimentally. A simple system consisting of one column packed either with cation or anion exchanger was first considered. A system of parapumps was then developed with more columns which were connected in series and packed alternately with cation and anion exchangers. Various methods of operation of parapumps are discussed. Enrichment and spliting of protein mixtures were examined. In most cases, the separation factor was defined at a steady state condition and was improved by increasing the number of cycles and columns.

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