Date of Award
Doctor of Engineering Science in Chemical Engineering
Chemical Engineering and Chemistry
Hung T. Chen
Dimitrios P. Tassios
John E. McCormick
This thesis presents the study of multi-column pH parametric pumping, a separation technique which applies the principle of parametric pumping and uses pH as control variable. Studies emphasize the mass transfer and the capability of separation by multi-column pH parametric pumping. Many operation modes of multi-column pH parapump are developed for varied objectives of separation. A Two-pH Levels Parapump is capable of enriching the product stream with solute components; a Three-pH Levels Parapump is capable of splitting components into two product streams. The separation capability of multi-column parapump is greatly superior to that of single-column parapump. As compared to cycling zone operation, parametric pumping gives a higher separation factor.
Hemoglobin and albumin are chosen for the experimental model system to demonstrate the separation capability of multi-column pH parametric pumping, and to verify the predictability of the models. Presented are the theoretical basis, mathematical models and methods, results of experimental studies and computer exploration, and the correlation of data with models.
Yang, Wei Tai, "Separation via multi-column pH parametric pumping" (1981). Dissertations. 1265.