Date of Award

Spring 1981

Document Type

Dissertation

Degree Name

Doctor of Engineering Science in Chemical Engineering

Department

Chemical Engineering and Chemistry

First Advisor

Hung T. Chen

Second Advisor

Deran Hanesian

Third Advisor

Dimitrios P. Tassios

Fourth Advisor

John Rausen

Fifth Advisor

John E. McCormick

Abstract

This thesis presents the study of multi-column pH parametric pumping, a separation technique which applies the principle of parametric pumping and uses pH as control variable. Studies emphasize the mass transfer and the capability of separation by multi-column pH parametric pumping. Many operation modes of multi-column pH parapump are developed for varied objectives of separation. A Two-pH Levels Parapump is capable of enriching the product stream with solute components; a Three-pH Levels Parapump is capable of splitting components into two product streams. The separation capability of multi-column parapump is greatly superior to that of single-column parapump. As compared to cycling zone operation, parametric pumping gives a higher separation factor.

Hemoglobin and albumin are chosen for the experimental model system to demonstrate the separation capability of multi-column pH parametric pumping, and to verify the predictability of the models. Presented are the theoretical basis, mathematical models and methods, results of experimental studies and computer exploration, and the correlation of data with models.

Share

COinS