Document Type


Date of Award

Spring 5-31-1990

Degree Name

Doctor of Engineering Science in Electrical Engineering


Electrical Engineering

First Advisor

Andrew Ulrich Meyer

Second Advisor

Rose Ann Dios

Third Advisor

Stanley S. Reisman

Fourth Advisor

Peter Engler

Fifth Advisor

Walter Weissman


Computers in medicine has brought new dimensions and better understanding of uncertainties in the field of medical sciences in the last decade. This thesis is focused upon the localization of neurological lesions in the human nervous system. It relates clinical neurological test outcomes to pathways of function or malfunction. Certain methods are proposed-empirical. stochastic. Deterministic-to estimate the spatial distributions of lesion probabilities.

First. a Bayesian model is presented to estimate the posterior probability of lesion from a priori information, based on the test outcomes. Due to unavailable data alternative methods and models are presented: Regression Analysis. Monte Carlo simulation, and finally a new model known as Logistic Sigmoid Nonlinearity is proposed for probability estimation. This dissertation analyzes each of these models and alternative methodologies in detail.



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