Date of Award

Spring 1994

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Electrical Engineering - (Ph.D.)

Department

Electrical and Computer Engineering

First Advisor

Stanley S. Reisman

Second Advisor

Walter N. Tapp

Third Advisor

Peter Engler

Fourth Advisor

Timothy Nam Chang

Fifth Advisor

H. Michael Lacker

Abstract

A noninvasive phase resetting experiment on human subjects was investigated. The phase response curve was estimated and was used to demonstrate cardiac phase resetting due to a vagal input. The estimated running phase response curve showed that the cardiac cycle resetting depended on the time and the amplitude of the vagal stimulation. The phase response curve was then studied using time circle analysis, topological analysis and nonlinear dynamics analysis. Also phase entrainment and stimulus frequency dependence of the phase response were evaluated. Further, the Van Der Pol model, Generalized Additive model and Knight and Peskin's model were used to simulate the phase resetting process so that the characteristics of the phase resetting can be better understood.

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