Document Type
Dissertation
Date of Award
5-31-2023
Degree Name
Doctor of Philosophy in Chemistry - (Ph.D.)
Department
Chemistry and Environmental Science
First Advisor
S. Mitra
Second Advisor
Edgardo Tabion Farinas
Third Advisor
Yuanwei Zhang
Fourth Advisor
Mengyan Li
Fifth Advisor
Vivek A. Kumar
Abstract
Nanomaterials have proven to be highly effective in the design and development of biomedicine. Complementary nanostructured hybrid particles show great promise in drug delivery applications. By improving functionalization, the physicochemical properties of the particles can be enhanced resulting in a high surface area, tunable hydrophilicity and porosity. These characteristics can provide a suitable environment for drug encapsulation, biocompatibility, high drug loading, and customizable release capabilities.
The formulation of drugs with poor water solubility faces multiple challenges, such as insufficient dissolution and inconsistent therapeutic efficacy, particularly when administered orally over an extended period. To overcome these challenges, some of the beneficial features of nanoparticles can be exploited. In this research presents the application of functionalized hydrophilic and nanosized particles for the synthesis of "fast dissolution" drug delivery systems. A variety of nanoparticles, hydrophobic drug molecules, and incorporation techniques were explored in this work, with a primary emphasis on oral delivery.
In this thesis, presents the development of several novel nanostructured particles, namely graphene oxide, polylactic acid (PLA), and polylactic co glycolic acid (PLGA) to make hybrid structures with the selected drug crystals. The chosen nanoparticles are dispersible in water, contain oxygenated functionalities and form stable colloidal dispersions. As a result, they can be introduced into hydrophobic drug crystals to significantly increase their water solubility and eventually bioavailability. The research focused on the development of hybrid drug crystals that were formed using antisolvent precipitation. The drugs studied were Griseofulvin, Sulfamethoxazole, Dexamethasone, Apixaban, and Megestrol acetate. The results showed that with the incorporation of approximately 1-2% hydrophilized GO and PLA, PLGA, the average dissolution rate increased 4-5 times with enhanced aqueous solubility, and the time for 50% and 80% dissolution time (T50 & T80) decrease significantly.
Recommended Citation
Islam, Mohammad Saiful, "Development of novel hybrid structures for fast dissolution of hydrophobic drugs" (2023). Dissertations. 1928.
https://digitalcommons.njit.edu/dissertations/1928
Included in
Analytical Chemistry Commons, Chemicals and Drugs Commons, Materials Chemistry Commons, Nanomedicine Commons, Pharmaceutics and Drug Design Commons
