Author ORCID Identifier
0000-0001-9201-3084
Document Type
Dissertation
Date of Award
12-31-2022
Degree Name
Doctor of Philosophy in Biomedical Engineering - (Ph.D.)
Department
Biomedical Engineering
First Advisor
Vivek A. Kumar
Second Advisor
Eun Jung Lee
Third Advisor
Jonathan M. Grasman
Fourth Advisor
Emi Shimizu
Fifth Advisor
Dominic Del Re
Abstract
Ischemic tissue disease is caused by a lack of circulation / blood supply to tissue. This can be treated by introducing a number of angiogenic (pro-blood vessel forming) factors into the tissue. This work presents strategies for ischemic tissue treatment utilizing a novel proangiogenic self-assembling peptide hydrogel platform. To demonstrate the utility of this platform, its use alone as an angiogenic therapeutic (both alone as a self-assembling hydrogel and with two-component systems), and its ability to vascularize implants is explored. Due to these angiogenic scaffolds demonstrating efficacy to regenerate microvasculature, this work evaluates diseases that can be treated by the regeneration of microvasculature - such as the soft tissue in the dental pulp and ocular microvessel healing.
Recommended Citation
Siddiqui, Zain, "Angiogenic supports for microvascular engineering" (2022). Dissertations. 1697.
https://digitalcommons.njit.edu/dissertations/1697
